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White Body Building Powder Selective Androgen Receptor Modulators SR9009
CAS No.: 1379686-30-2
Appearance: White powder
Usage: SR9009 increase exercise endurance and weight loss, research chemical.
Packing: foil bag or as required
A new drug known as SR9009, which is presently under development at TSRI (The Scripps Research Institute) has been shown to considerably boost exercise endurance in animal models. Scientists think these discoveries may lead to improved cures for individuals suffering from illnesses that severely limit exercise endurance such as obesity, COPD (chronic obstructive pulmonary disease), congestive heart failure and also in the deterioration of muscle capacity linked with aging.
The drug was developed by Professor Thomas Burris who found that it was capable of reducing obesity in animal models, particularly mice. SR9009 which is an easy to dose oral compound can increase the level of metabolic activity in skeletal muscle of mice. The treated mice became lean, developed larger muscles and had a 50% increase in running abilities which imitates the effects of aerobic exercise.
The SR9009 binds to Rev-erbα (one of the body's natural molecules) which influences lipid and glucose metabolism in the liver, the creation of fat-storing cells and the reaction of macrophages (cells that eliminate dying or dead cells) during inflammation.
1. SR9009, which is currently under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice. Treated mice become lean, develop larger muscles and can run much longer distances simply by taking SR9009, which mimics the effects of aerobic exercise. If similar effects can be obtained in people, the reversal of obesity, metabolic syndrome, and perhaps Type-II diabetes might be the very welcome result.
2. The drug was developed by Professor Thomas Burris, who found that it was able to reduce obesity in populations of mice. It binds to and activates a protein called Rev-ErbAα, which influences fat and sugar burning in the liver, production of fat cells, and the body's inflammatory response.
3. SR9009 is a research drug that was developed by Professor Thomas Burris of the Scripps Research Institute as an agonist ofRev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA)with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ. Activation of Rev-erb-α by in mice SR9009 increases exercise capacity in mice by increasing mitochondria in skeletal muscle.
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